Cloud manufacturing is a new, networked and intelligent manufacturing model that is service-oriented, knowledge based, high performance, and energy efficient. In this model, state-of-the-art technologies such as informatized manufacturing, cloud computing, Internet of Things, semantic Web, and high-performance computing are integrated in order to provide secure, reliable, and high quality on-demand services at low prices for those involved in the whole manufacturing lifecycle. As an important part of cloud manufacturing, cloud simulation technology based on the COSIM-CSP platform has primarily been applied in the design of a multidisciplinary virtual prototype of a flight vehicle. This lays the foundation for further research into cloud manufacturing.