This paper gives an overview of the generation and transmission of 450 Gb/s wavelength-division multiplexed (WDM) channels over the standard 50 GHz ITU-T grid at a net spectral efficiency (SE) of 8.4 b/s/Hz. The use of nearly ideal Nyquist pulse shaping, spectrally-efficient high-order modulation format, distributed Raman amplification, distributed compensation of ROADM filtering effects, coherent equalization, and high-coding gain forward error correction (FEC) code may enable future 400G systems to operate over the standard 50 GHz grid optical network.